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Pharmacological and physiological effects of cannabidiol: a dose escalation, placebo washout study protocol
This study will assess escalating doses of CBD from 5 to 30 mg CBD/kg/day, monitoring physiological factors like cerebral hemodynamics and psychological factors such as sleep and anxiety. The goal is to identify an optimal dose to improve recovery and reduce the risk of traumatic brain injuries in contact sport athletes.
Parkinson’s Disease and the Cardiac Cycle: A Rapid Literature Review and Case Series
Studies suggest that patients with Parkinson’s Disease experience subclinical systolic dysfunction, although findings remain inconsistent. The case series provided important insights, with consistent cardiac parameters observed over a 6-week period, including a heart rate of 67–71 bpm and systolic time intervals ranging from 332 to 348 ms.
Effect of exercise on sleep quality in Parkinson’s disease: a mini review
Parkinson’s Disease (PD) not only affects motor function but also causes sleep disturbances, such as reduced slow-wave sleep. While medications improve motor symptoms, their impact on sleep is unclear. Recent research highlights exercise, including aerobic, resistance, and balance training, as a promising approach to enhance sleep quality in PD patients. Exercise may help clear toxins and increase brain-derived neurotrophic factors, potentially improving sleep. However, further research is needed to understand the underlying mechanisms.